ABSTRACT
Genus Vitex is largely used throughout the world (Benin, Burkina Faso, Ethiopia, Ghana, India, Lesotho, Nigeria, Senegal, South Africa) for various care such as: anti-inflammatory, antibacterial, hepatocuractive, intestinal troubles. Among the plurality of known Vitex, the most exploited in Burkina Faso are Vitex diversifolia Bak and Vitex doniana Sweet. Then, the aim of this study is to summarize traditional uses, phytochemistry and pharmacological activities of 2 local species of Vitex. The results of this study show that the species of this genus are rich in polyphenolic compounds, minerals and vitamins. These founding can justify the many uses in traditional medicine.
ABSTRACT
Pandiaka angustifolia (Vahl) Hepper, a species belonging to Amaranthaceae’s family is used in traditional medicine of Burkina Faso for the treatment of several diseases. The aim of this study was to evaluate the phenolics and flavonoids content, the antioxidant capacity, the lipoxygenase and xanthine oxidase inhibition potentials of Pandiaka angustifolia hydroacetonic macerate and fractions. Assay revealed that the Dichloromethane Fraction (DCMF) possess the best inhibitory activity of lipoxygenase, a key enzyme involved in inflammatory process with 83.84±1.89% of inhibition, as regards Xanthine Oxidase (XO) inhibiting percentage, n-hexane fraction (n-HF) exhibited the highest percentage of inhibition with 76.22 ± 4.78% at a concentration of 100μg/ml. Phenolics and flavonoids content in fractions and hydroacetonic macerate evaluation showed that hydroacetonic macerate possess the highest rate in total phenolic and the Dichloromethane fraction (DCMF) the highest rate in flavonoids content. This study showed that the apolar fractions of P. angustifolia is a potential natural source for the treatment of oxidative stress and inflammatory related diseases.